Calls for ibuprofen sale restrictions after study finds cardiac arrest risk

There have been fresh calls for restrictions on the sale of the painkiller ibuprofen after another study found it heightens the risk of cardiac arrest.

Taking the over-the-counter drug was associated with a 31% increased risk, researchers in Denmark found.

Other medicines from the same group of painkillers, known as non-steroidal anti-inflammatory drugs (NSAIDs), presented an even higher risk, according to the findings published on Wednesday in the European Heart Journal.

Diclofenac, available over the counter in the UK until 2015 and still taken on prescription, raised the risk by 50%.

Prof Gunnar Gislason of the University of Copenhagen, who led the study, called for tighter controls on the sale of ibuprofen and other NSAIDs. He said: “Allowing these drugs to be purchased without a prescription, and without any advice or restrictions, sends a message to the public that they must be safe.

“The findings are a stark reminder that NSAIDs are not harmless. Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest.”

The findings are the latest to raise alarm about the use of NSAIDs. Last September a study in British Medical Journal found they were linked to an increased risk of heart failure. Previous studies have linked the drugs to abnormal heart rhythm – which can cause heart failure – and an increased risk of heart attack and stroke if taken regularly.

Gislason urged people with heart problems to avoid ibuprofen and other NSAIDs. “NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patients with cardiovascular disease or many cardiovascular risk factors,” he said.

“I don’t think these drugs should be sold in supermarkets or petrol stations where there is no professional advice on how to use them.”

Gislason suggested they should only be taken after consulting a doctor. “Over-the-counter NSAIDs should only be available at pharmacies, in limited quantities and in low doses,” he said.

He added: “The current message being sent to the public about NSAIDs is wrong. If you can buy these drugs in a convenience store then you probably think: ‘They must be safe for me.’

“Our study adds to the evidence about the adverse cardiovascular effects of NSAIDs and confirms that they should be taken seriously and used only after consulting a healthcare professional.”

The Danish investigators studied data on almost 29,000 patients who suffered an out-of-hospital cardiac arrest recorded in Denmark between 2001 and 2010. They found that use of any NSAID raised the likelihood of cardiac arrest by 31%.

The researchers speculated that the results could be explained by the effect of the drugs on the cardiovascular system, as they influence platelet aggregation and the formation of blood clots. They may also cause arteries to constrict, increase fluid retention and raise blood pressure.

Gislason said people should not take more than 1,200mg of ibuprofen in one day.

The Proprietary Association of Great Britain, the trade body representing manufacturers of over-the-counter medicines said the study had “several limitations,” and insisted that NSAIDs are safe.

John Smith, its chief executive, said: “Information about daily dosage was only based on estimates rather than accurate data and didn’t account for over-the-counter use. Prescribed NSAIDs would normally contain a higher dosage than those medicines available over-the-counter and would typically be used for longer durations.”

He added: “NSAIDs available over-the-counter, such as ibuprofen, are an effective and appropriately safe way to provide short-term pain relief if used in accordance with the clear on-pack instructions and the patient information leaflet inside. NHS Choices recommends NSAIDs to help relieve pain, reduce inflammation, and bring down a temperature.

“It is important for people with a history of heart disease or other long term condition to speak to a pharmacist before taking any over the counter medicine to check for any potential drug interactions or health concerns.”

Calls for ibuprofen sale restrictions after study finds cardiac arrest risk

Top Doctors Warning- Anyone Over 40 Should Stop Taking Ibuprofen Immediately

It seems common for us to be use ibuprofen for nearly every symptom like Headaches, toothaches, back pain. According many medical experts around the world claim that these drugs (nonsteroidal anti-inflammatory drugs, or NSAIDs), have serious side effects and are a major cause of drug-induced injury.

Ibuprofen doesn’t cure the pain and in the long run it is toxic to the heart muscle. In fact, using long period of time may even cause death.

More Harm Than Good

In 2005, the FDA issued a warning about ibuprofen, saying it significantly increases one’s risk of heart attack or stroke. Keep in mind that the FDA approves of some pretty terrible medications, but even they are raising a red flag when it comes to this over the counter drug. The organization has since emphasized the warning with the following information

-Ibuprofen significantly raises the risk of heart attacks and strokes, even after short term use.
-The risk increases with higher doses of NSAIDs taken for longer periods of time.
-The risk is somewhat higher for people who already have heart disease.

Additionally, the risk is much higher for people older than 40, and the chances for these people to develop heart problems are extremely high.

The Natural Alternative of Ibuprofen

Turmeric isn’t just a spice, it’s a natural medicine. In fact, it works better than drugs in fighting disease such as fatty liver disease, pain, arthritis, weight loss, depression and even cancer.

The active compound in turmeric is curcumin, it has analgesic properties. It reduce the sensation of pain by triggering a response in the opioid receptors in the brain. Unlike drugs, though, turmeric doesn’t cause addiction.

Homemade Turmeric Supplements

Ingredients:

1/3 cup organic, ground turmeric
big pinch of ground black pepper
3 tbsp raw, organic honey
1 tbsp melted coconut oil

Instructions:

-Mix all ingredients together in a bowl to make a paste.
-Take pinches of the turmeric paste and roll them into small balls.
-Place in freezer for about 1 hour and remove.
-Store in a glass container and keep it in your refrigerator.
-Take 2-3 a day.

Turmeric Drink

-In a glass mix 1 tbsp. turmeric powder, 1 cup of honey and the juice of 1 lemon.
-Add 1 of the mixture into a cup of warm water or tea 3 times a day.

Additional Sources:

1) https://dailyhealthpost.com

2) http://juicing-for-health.com

3) http://www.naturalhealingmagazine.com

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Top Doctors Warning- Anyone Over 40 Should Stop Taking Ibuprofen Immediately

Ibuprofen could avoid premature ageing by combating arthritis, study displays

They believe it could do the very same for humans displaying signs of reduced-grade chronic irritation, therefore protecting them from the ravages of age.

Nonetheless researchers stressed that in the experiments, ibuprofen only benefited mice whose charge of ageing had been accelerated. It had no effect on ”wild type” mice with normal amounts of irritation and ageing.

They warned the drug should not be witnessed as a possible ”fountain of youth” panacea with the electrical power to defeat ageing in the common person.

The group is now preparing for long term clinical trials by learning published information from other researchers and hunting for inflammation markers in cohorts of patients with age-associated diseases this kind of as Parkinson’s.

Lead scientist Professor Thomas von Zglinicki, from the Institute for Ageing and Overall health at the University of Newcastle, explained: ”People age differently, some much faster than other folks.

”We know already that quicker ageing is typically related with activated markers of chronic irritation. With these results we can now critically commence thinking about irritation as a possible driver of accelerated ageing and how we may be ready to delay it.

”Inflammation has side effects and I genuinely would not advise that everyone should take anti-inflammatories day-to-day. But it might be beneficial to check out continual irritation status, and if that is enhanced, there may well be a case for making use of anti-inflammatories.”

Scientists have lengthy-acknowledged that irritation accompanies ageing, but regardless of whether or not it plays an energetic role in the process has been unclear.

The new research, reported in the journal Nature Communications, confirms that chronic irritation is much more than an innocent bystander.

The ”knockout” mice employed in the examine lacked a gene that typically limits their inflammatory response but have been otherwise totally wholesome.

Provided the exact same diet regime and residing conditions as wild-type mice, they aged twice as quick. Mirroring results noticed in humans, they skilled premature hair reduction, fur greying, excess weight reduction, impaired neuromuscular co-ordination, and heart difficulties.

They also took less pride in their appearance, marked by scruffy fur and infrequent grooming, and each their typical and optimum lifespans have been diminished.

Critically, the standard regenerative capacity of their livers and intestines was lost.

”These effects could be improved with anti-inflammatory treatment method,” stated Prof von Zglinicki. ”Basically, the knockout mice were brought back to standard by ibuprofen.”

In exams, livers regrew in treated knockout mice right after part of the organs had been removed.

The hyperlink among irritation and ageing was traced to the release of destructive reactive molecules, known as oxygen free radicals, which damaged DNA and telomeres – the protective ”caps” on chromosomes.

Telomere loss led to the arrested growth and standard working of cells, a state acknowledged as ”senescence” which is imagined to contribute to ageing. Higher senescence in turn created far more free radicals, creating a vicious cycle.

The accumulation of senescent cells was blocked each by the therapy of anti-inflammatory medication such as ibuprofen and antioxidants, the scientists identified.

Diana Jurk, a researcher in Prof von Zglinicki’s group, mentioned: ”The most crucial end result of the examine is that treatment with a straightforward and inexpensive anti-inflammatory drug, ibuprofen, could reverse the progression of cell senescence and restore the ability of tissues to regenerate.”

The scientists are now turning their focus to human patients, such as one cohort of all around 200 people with Parkinson’s ailment who may be impacted by accelerated ageing.

”We need to have to see which sufferers do really have enhanced inflammatory markers ahead of pondering about intervention trials,” stated Prof von Zglinicki.

Even though certain unusual inherited conditions massively pace up the ageing method, the price at which anybody ages varies tremendously in between individuals.

”Faster biological ageing is linked to a number of age-connected conditions, which includes heart illness and a variety of cancers.

“‘Even in people inside of the regular lifespan variety there can be a huge distinction,” explained Prof von Zglinicki.

”Some may die at 60, others in their seventies, while other individuals make it to 100. The vast majority of people who die youthful endure from cardiovascular illness.”

He added: ”There is good epidemiological proof to show that faster ageing is linked with inflammation.”

Ibuprofen could avoid premature ageing by combating arthritis, study displays

European Regulators Investigate Cardiovascular Safety Of Ibuprofen

The European Medicines Agency announced on Friday that it had initiated a overview of the cardiovascular safety of ibuprofen when taken in high doses over  an extended period of time. The review will be carried out by the Pharmacovigilance Risk Assessment Committee (PRAC).

The EMA explained that people taking ibuprofen ought to proceed to take it as extended as they follow the package deal label or the guidelines of their doctor or pharmacist.

The cardiovascular threat of all non-steroidal anti-inflammatory medicines (NSAIDs) have been below near scrutiny for a amount of years. The enhanced danger connected with a single group of NSAIDs, the COX-two inhibitors, has been acknowledged for much more than a decade. Researchers have also located evidence for cardiovascular difficulties with the NSAID diclofenac.

The agency mentioned it had located no proof for a problem in men and women taking doses significantly less than two,400 mg/day or for quick periods of time. ”Ibuprofen is one of the most broadly employed medicines for soreness and inflammation and has a properly-known safety profile, specifically at normal doses,” the EMA explained.

European Regulators Investigate Cardiovascular Safety Of Ibuprofen