Prospect etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster
Prospect etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster

30 Temmuz 2016 Cumartesi

Airport drinks ban? What a joyless prospect | Barbara Ellen

At first glance, the proposed crackdown on the sale and consumption of alcohol in British airports seems a no-brainer. Why should airport staff or plane crew be forced to deal with abusive or violent passengers? In an era of critical security issues, why should police time be wasted on inebriates? Does it enhance the journey when people have alcohol-fuelled “disagreements” in their seats or someone vomits into their cupped hands on take-off?


On this note, I’d like to apologise for my past misbehaviour. In retrospect, it was a bad idea to ask the airport bar guy for a Jack Daniel’s with the mixer of… two more Jack Daniel’s. To decant vodka into an Evian bottle as a precaution against flight attendants ignoring us. To spend transatlantic red-eyes ranting drunkenly about relationship disasters (that were never my fault, oh no!).


And while there’s a tendency to look back on the time when you were allowed to drink and smoke on planes as a study in Mad Men-style elegance, I belatedly accept that this bears little resemblance to what usually happened: over-ordering drinks, lighting up duty-free fags so often that your seat resembled a hazy micro-climate, rising from said seat with as much plastered dignity as you could muster to weave to the loos, occasionally clutching sleeping strangers’ heads for balancing purposes, sometimes falling on to sleeping strangers, and so on…


Irritating, right? Who’d want to sit next to that? Not me, not any more, but that’s the point – my misbehaviour mainly occurred back in my music hack/“rock chick” days. I’m older now, officially no fun any more, firmly at the “tut, tut, I judge you” stage of the human life cycle.


But just because I’m resolutely past it where alcohol and flying is concerned, does this mean that everyone else has to fall in line? Moreover, are we all supposed to pretend not to notice the unlovely whiff of class contempt swirling around this planned curbing of public hedonism?


To my mind, this proposed legislation seems largely aimed at youthful and/or working-class travellers, with an unexpressed but palpable nod to wayward hen parties, disorderly stag outings, raucous festivals or the kind of package deals that offer two weeks of all-inclusive, unbridled misbehaviour in the sun with your post-Brexit depleted euros.


One can more readily endorse other restrictions on drinking. These proposals came in the same week that a Latvian Air Baltic pilot was sentenced to six months in jail for attempting to fly while seven times over the legal limit. Which, I read, is a very rare occurrence, though “rare” doesn’t sound that soothing when planeloads of passengers are involved.


Elsewhere, there’s a study reporting a rise in middle-class people taking class A drugs such as cocaine and ecstasy and a drop in working-class people doing it. Which raises interesting issues – sometimes perhaps it’s not about the illegality of what you consume, rather the setting in which you do it and whether you’re a public nuisance.


But is this yet more class-based hypocrisy, with an element of the “right” and “wrong” kinds of hedonism? I couldn’t care less if middle-class people perk up their dull dinner parties with a bit of toot. However, I do feel that this quasi-acceptable brand of “sophisticated” illegality could bear contrasting with legal drinkers in airports, most of whom, remember, don’t cause trouble.


Isn’t this what’s going on here – proposed legislation that affects everybody, but is actually an attempt to target and control people who have been outrageously pre-branded as “out-of-control lairy proles”? I repeat, it’s never right for airport staff, flight crew or anyone else to be drunkenly abused or attacked.


However, that’s a totally separate issue to people merely drinking. Most manage to do so without committing any criminal or antisocial acts or even being as profoundly irritating as I used to be.


Let’s do it, let’s put Victoria Wood on a pedestal



Victoria Wood: deserving of a statue.


Victoria Wood: deserving of a statue. Photograph: ITV

Victoria Wood’s brother, Chris Foote Wood, is proposing a statue of the comedy genius, who died in April, in her home town of Bury. He envisages it in the style of the Eric Morecambe statue on Morecambe promenade, featuring Wood at her piano or in her mac and beret.


While there’s dark talk of crowdfunding, I hope that Bury council is able to stump up for this. I was going to ask of whom Bury could possibly be prouder. As it happens, Bury has been fairly stuffed with notable people, including Robert Peel, who already has a statue, Danny Boyle, Dodie Smith and footballers Gary and Phil Neville.


However, Wood occupies a cherished place in the communal British heart. As with that other recent devastating loss – Caroline Aherne – Wood was an ordinary woman who proved to be extraordinary; even as her talent took her to great heights and new places, she still managed to remain true to her roots.


Personally, I’d be satisfied only if Bury immortalised the entire Acorn Antiques cast in the town square, but never mind me. Whatever form the statue takes, come on, Bury, let’s do it.


Walking back to happiness? It’s easy



Walking: easy, quiet and enjoyable.


Walking: easy, quiet and enjoyable. Photograph: Alamy Stock Photo

The health secretary, Jeremy Hunt, has expressed concern about a study that says that average walking levels have fallen by more than a third in the past three decades. Hunt sports a Fitbit to track his steps, though sadly it’s proving inefficient at monitoring the calories burned while grovelling to Theresa May to keep his job.


The slide in how much we walk is an issue that goes beyond health. On top of my sedentary job, I’d classify myself as fairly bone idle – I’m often surprised not to find a thick web forming between myself, the sofa and the television.


However, I don’t drive (too stupid to learn), so I’ve always walked pretty much everywhere, whatever the weather, within manageable distances, and I’ve made my children do the same.


Some people are amazed that I’m happy to plod about like this. I, in turn, am astonished by some of their short car journeys as well as the way that hordes of commuters are happy to stand waiting for a bus that is nearing the end of its route.


While I’ve been the grateful recipient of many a lift, I find this bus-behaviour mystifying. If you can walk, why not do it? Why would anybody choose a rammed bus over the blessed autonomy of their own two feet?


Some people need to realise that those long flesh-and-bone things hanging from their torsos are there for a reason, other than as a place to hang their jeans and display their shoes. With all the exhibitionist displays of public fitness going on (cycling, jogging), it seems strange and sad that the easiest, quietest, most enjoyable form of exercise of all could be grinding to a halt.


Comments will be opened later today



Airport drinks ban? What a joyless prospect | Barbara Ellen

4 Haziran 2014 Çarşamba

The Grim Prospect Of Life Without Antibiotics

It was not until the many years just following Planet War II when streptomycin, the initial actually broad-spectrum antibacterial agent, came onto the industry, and penicillin began to be extensively available that the Golden Age of antibiotic therapy truly started.  Just before that, even seemingly trivial infections of the skin, lungs or other organs could lead to sepsis and death.  We could now be on the verge of returning to a pre-antibiotic era, a prospect that public health authorities find terrifying.


Bacteria are champions of Darwinian assortment: As we try to kill them with antibiotics, they mutate in myriad techniques in buy to survive.  And they have quite a repertoire: Amid other tricks, they build less permeable walls to hold the antibiotics out, produce techniques to degrade or extrude them or alter the intracellular targets so that the antibiotics no longer work on them.  Bacteria can even transfer these evolutionary adaptations from one species to another, generating it ever far more critical for us to come up with new antibiotics that function via novel mechanisms.  It is a in no way-ending escalating arms race, and the harsh actuality is that the bacteria are winning it.


More and more, microorganisms are establishing resistance to not only to single antimicrobial agents, but to a number of.  These latter organisms are named multidrug-resistant, or MDR, strains.  In some situations, the microorganisms have become so resistant that no obtainable antibiotics are successful towards them.  This led Dr. Arjun Srinivasan, assistant director of the Centers for Illness Control and Prevention (CDC), to paint this dire picture final yr:


We are rapidly running out of therapies to treat some of these infections that previously had been eminently treatable. There are bacteria that we encounter, especially in well being-care settings, that are resistant to almost all — or, in some circumstances, all — the antibiotics that we have obtainable to us, and we are therefore coming into an era that men and women have talked about for a extended time. . . We’re in the post-antibiotic era.  There are patients for whom we have no treatment, and we are actually in a place of possessing a patient in a bed who has an infection, some thing that 5 many years in the past even we could have treated, but now we can’t.



Methicillin-Resistant Staphylococcus aureus (MRSA)

Methicillin-Resistant Staphylococcus aureus (MRSA) (Photograph credit: NIAID)




According to the CDC, in 2011 there have been about 3 quarters of a million hospital-acquired infections in U.S acute care hospitals, and about 75,000 sufferers died in the course of their hospitalizations.  This daunting tally excludes individuals who acquire infections in other well being-care settings, such as outpatient surgical treatment centers, the place far more than 60% of all operations are now carried out, and extended-term care services.  As pathogens this kind of as methicillin-resistant Staphylococcus aureus (MRSA) have moved beyond overall health-care amenities, drug-resistant infections have become frequent in the neighborhood at massive.


Drug resistance has critical implications.  Folks infected with drug-resistant organisms are far more very likely to have longer and much more costly hospital stays and are more very likely to die as a result of the infection.  When the 1st-line drug of selection for treating an infection won’t work, physicians have to resort to 2nd- or third-choice medicines that may possibly be less successful and a lot more toxic.


At the identical time that bacterial resistance to antibiotics is escalating, the number of drug and biotech companies building new antibacterials is shrinking.  This decline is due to a variety of factors, which includes lack of industry productivity, the reduced return on investment of antibacterials compared with other therapeutics, problems in identifying new compounds with standard discovery approaches, regulatory specifications that require large and complicated clinical trials for approval, and initiatives that motivate antibiotics to be utilised as sparingly as achievable (to lessen the spread of resistance).


Neither the federal government nor private scientific philanthropy is adequately supporting study on antibiotics and antibiotic resistance.  The National Institutes of Health’s Nationwide Institute of Allergy and Infectious Conditions is “funding and conducting study on numerous aspects of antimicrobial (drug) resistance, which includes basic investigation on how microbes create resistance, new and quicker diagnostics, and clinical trials created to locate new vaccines and treatment options successful against drug-resistant microbes.”  And an additional agency inside the U.S. Department of Health and Human Providers, the Biomedical Superior Study and Development Authority (BARDA), funds antibiotics R&ampD, which includes expensive late-stage (Phase III) clinical trials, at some of the handful of pharmaceutical businesses nonetheless in the area.  Since 2010, BARDA has partnered with six drug makers and has sponsored 9 molecular candidates in Phase II/III clinical trials to test the drugs’ efficacy towards biothreats (e.g., plague) and some of the worst bacterial pathogens now threatening society.


A 2002 modify in FDA demands for the clinical testing of antibiotics helped to create the shortage of new antibiotics.  To boost the statistical power – and therefore, the self-assurance degree — of Phase III antibiotic clinical trials, FDA a lot more than doubled the variety of patients essential.  As antibiotics researchers David Shlaes and Robert Moellering observed in that very same 12 months, because in the pharmaceutical industry business considerations play a essential element in setting R&ampD priorities, corporate


applications with modest possible markets and massive expenses are automatically deprioritized unless of course there is some other, overriding strategic concern to be deemed.  Thus, 1 unintended end result of promulgating these guidelines will be a reduce in the quantity of firms performing antibacterial investigation.


Their prediction was accurate: Given that 2002 all but a handful of the significant pharmaceutical firms have abandoned their antibiotics R&ampD programs.


From 2009 to 2012, in part at the urging of members of Congress who had robust opinions but minor understanding of the clinical testing of antibiotics, FDA’s policy toward antibiotics testing grew to become so threat-averse and punitive that clinical trials of new antibiotics nearly ground to a halt.  FDA even proposed that sufferers enrolled in clinical trials for hospital-acquired pneumonia would be ineligible if they had received one more antibiotic inside of thirty days prior to their participation, making this kind of studies nearly impossible to conduct in the United States.


In July 2013, nonetheless, the FDA launched new draft recommendations for the conduct of antibiotic clinical trials – element of a self-described “reboot” of policy at the agency.  The new guidelines may assist, but some specialists, this kind of as UCLA Professor of Medication Brad Spellberg, have warned that the new suggestions really don’t signify considerable alter, and that much far more improvement is necessary for trials to become feasible once again.


FDA must adopt a promising concept initially proposed by the Infectious Ailments Society of America (IDSA) known as the Restricted Population Antibacterial Development (LPAD) pathway, through which “a drug’s safety and effectiveness would be studied in considerably smaller, a lot more rapid, and significantly less pricey clinical trials” — equivalent to the way “orphan drugs” are produced for uncommon ailments. As soon as accepted, LPAD-kind products would be labeled for use in modest, effectively-defined populations of individuals for whom the drugs’ rewards had been shown to outweigh their hazards.  In this model, studies of potential new antibiotics would want to enroll hundreds of patients as an alternative of the 1000′s now required and could be carried out fairly rapidly.


Nevertheless, as Shlaes and Moellering have pointed out, to revive antibiotic R&ampD, along with regulatory reform we will also need “value-based” pricing, so that return on investment from antibiotic improvement is comparable to that of other drug classes.


Consequently, we need to assume LPAD-design antibiotics to cost as considerably as $ twenty,000-30,000 per course.  This is not unreasonable, provided that several marginally successful cancer medicines value a lot of instances that quantity a new two-drug regimen, sofosbuvir and ribavirin to deal with Hepatitis C, is about $ 84,000 wholesale and Truvada, the drug combination of emtricitabine and tenovir for HIV prophylaxis, costs $ 15,000 per yr.  In 2010, Forbes compiled a checklist of 9 small-employed drugs whose cost for the average patient exceeded $ 200,000 per yr.


One particular proposed legislative correct for the market place failure in antibiotics growth is the bipartisan “Developing an Revolutionary Technique for Antimicrobial Resistant Microorganisms (DISARM) Act of 2014,” which would demand the Centers for Medicare and Medicaid Companies (CMS) to reimburse considerably a lot more for LPAD-like antibiotics.  Currently, hospitals may possibly truly get rid of funds since reimbursements fail to cover the expense of the medication.  (Hospitals would not be encouraged to more than-use the medication, however, since reimbursement would cover only their expense, but no profit-margin.)



The Grim Prospect Of Life Without Antibiotics